This is not a bug.
Reshade come with pre-defined settings. For some games nothing to do.
In Fallout 4 you have to change the values in Edit global preprocessor definitions to have the correct depth map (depth buffer).
Depth buffers are an aid to rendering a scene to ensure that the correct polygons properly occlude other polygons.
Many shaders (like any ambient occlusion effect, depth-of-field, distance fog, Ray tracing) need a correct depth map to work properly.
Believe me, 2 minutes in-game to repear the Misaligned Depth Buffer.
So, go in game, open Reshade Menu and select the shader called DisplayDepth
If your image look's like that


Thats mean your shaders works properly.
Left Normal map (the surfaces look smooth and the background is colored). RESHADE_DEPTH_INPUT_IS_LOGARITHMIC
Right Depth map (close objects are black, distant objects are white). RESHADE_DEPTH_INPUT_IS_REVERSED
If not, probably a black screen in right, follow the next instructions
Select only the shader called DisplayDepth

Go to Add-ons and select Copy depth buffer before clear operations
New since Version 5.2.0 : select Copy depth buffer before fullscreen draw calls
There is an additional option if you have enabled DLSS (RTX graphic card)

Return to Home and at the bottom select Edit global preprocessor definitions
Change the value in RESHADE_DEPTH_INPUT_IS_REVERSED to 0

At the bottom Reload. It's done. The Misaligned Depth Buffer is repear.
Unselect DisplayDepth and select your shaders.

Reload and you are finish.
7 comments
Edit: Scratch that... had to go into addons and tick a different box and now it works
This is not a bug.
Reshade come with pre-defined settings. For some games nothing to do.
In Fallout 4 you have to change the values in Edit global preprocessor definitions to have the correct depth map (depth buffer).
Depth buffers are an aid to rendering a scene to ensure that the correct polygons properly occlude other polygons.
Many shaders (like any ambient occlusion effect, depth-of-field, distance fog, Ray tracing) need a correct depth map to work properly.
Thank you for your message.