"There's not a lot they can do yet other than edit textures and a couple other things, because the Creation Kit isn't out," Howard told Tech Insider. "And once it's out early next year, I think the sky's the limit."
- Dec 3, 2015, Business Insider: “What to expect from 'Fallout 4' in 2016”

As you’re probably aware, the 1.5 update is currently in open beta and will likely be officially released very soon and with it comes the long-awaited Fallout 4 Creation Kit. Along with this, Bethesda is changing the way plugins will be handled by the game.

The result is that mod management software, including our own Nexus Mod Manager, will need to be updated to adhere to the new standards being set by Bethesda. Thankfully, by providing access to the beta updates, Bethesda has allowed us to be able to preemptively make the changes needed to NMM so that when the patch does arrive, you will be affected as minimally as possible. However, there are some things you need to be aware of:

When the Fallout 4 1.5 update is released, NMM users will need the to have the latest version installed. With that done, the first time you open NMM with the Fallout 1.5 update installed, all of your plugins will no longer be enabled. If you take advantage of NMM’s profile system, this can be most simply resolved by selecting “Import load-order” from the “Profile” menu, which will enable all of the the plugins associated with that profile at once. Otherwise, if you are not using an NMM profile, you will need to enable each plugin again in the usual fashion, either by selecting the plugins and clicking the green check-mark, or simply double-clicking each one. This is only a one-time thing that you will be reminded of the first time you open NMM with the 1.5 update installed.

Other mod management software (such as Mod Organizer) may handle this differently so be sure to check with them to understand what steps you may need to take. To those of you that prefer manual installation, the process has also been slightly streamlined so we’ve updated the wiki accordingly.

It’s important to remember that the amazing work that the Fallout 4 modding community has accomplished so-far has all been done without official support or tools from Bethesda. The pending release of the Creation Kit will not only provide the tools needed to make more expansive changes to the core game that we’re all looking forward to, but also likely more education directly from Bethesda themselves. Hopefully all of this leads into a healthy relationship between us and the new Bethesda.net mod repository, as well as the upcoming console modding community.

Very exciting times, indeed! This is going to be a unique transition period for the Fallout 4 community and we’re hoping to help make it as seamless and fruitful as possible. We’ll be sure to keep you updated with any developments!