These are the settings that I have been happy with and have settled with for some of the mods that include an ini file (SSE Fixes, SSE Engine Fixes, SSE Display Tweaks ... and more)
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These settings are optimized for maximum performance and a 144fps cap (that you can change to your preference in the display tweaks INI file) Run the reg file once so that skyrim and skse always run as high priority in task manager I found that it helps mitigate crashes when alt tabbing a lot or when enabling some experimental options like bSpeedUpNativeCalls from Papyrus Tweaks NG ini (it is disabled in the most recent version, and enabled in the older archived version)