You can but it's not recommended. The Engine can only handle so many different worldspaces including DLCs and saves will bloat. That said, two should be doable on one save then you can swap out for another two and have less problems than 4 different massive worldspaces.
Trying to do this right now. Shame there isn't any more massive worldspace mods I can cram into the mix. Save bloat shouldn't be an issue with a good load order and enough compatibility patches to get everything playing nicely.
After some fiddling with Vortex and its menus, I think I found out how to make this work. 1:In Vortex, right-click on Western Wastelands. 2:Click on "manage file conflicts" 3:Under the tab that says "main" you should see the mod files that conflict with it. 4:Click on the selection bars to the right. 5:Change whatever mods are marked as "default" to Western Wasteland. 6:This SHOULD set Western Wastelands as the main menu now.
Okay I had that same issue, but now it's fixed, I don't know what I did, but here's the process I went through. I uninstalled New Vegas and reinstalled it. Made a new instance, transferred my mods to the new instance, uninstalled and reinstalled New Callifornia, redownloaded any mods I couldn't download through MO2 (EG: Script Extender) I ran LOOT, I cleaned any mods that needed cleaning, + I cleaned YUP and FPGE and the patch the links them. And now it works. Like I said I don't know what I did as I did all that for a different unrelated reason lol, but I hope this helps.
Anyway to combine this with FGPE and DUST? Like not just the menu but the whole of the mods? Tryna do like, you do New Cali, then vanilla-all other mods- dlc-Hoover Dam, then we go off to the Frontier and while we're doing that DUST happens back in Vegas then that's it.
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1:In Vortex, right-click on Western Wastelands.
2:Click on "manage file conflicts"
3:Under the tab that says "main" you should see the mod files that conflict with it.
4:Click on the selection bars to the right.
5:Change whatever mods are marked as "default" to Western Wasteland.
6:This SHOULD set Western Wastelands as the main menu now.
Please advise.